郑劼(邮箱:jessiezheng@njucm.edu.cn), 博士,副教授,硕士研究生导师。江苏省“双创博士”。中国药理学会抗炎免疫药理专委会青年常务委员。
主要从事中药抗炎免疫药理研究。先后主持国家级与省部级自然科学基金课题5项,相关成果发表SCI论文16篇,授权专利1项,参译著作1部,获江苏药理科学技术奖三等奖、江苏省高等学校科学技术研究成果奖三等奖。目前担任Acta Pharmaceutica Sinica B、Phytomedicine、南京中医药大学学报等杂志审稿专家。
代表性研究论文
(1) Zheng J#, Gu A#, Kong L, Lu W, Xia J, Hu H, Hong M. Cimifugin Relieves Histamine-Independent Itch in Atopic Dermatitis via Targeting the CQ Receptor MrgprA3. ACS Omega. 2024 Jan 31;9(6):7239-7248.
(2) Gu X, Chen Y, Qian P, He T, Wu Y, Lin W, Zheng J*, Hong M*. Cimifugin suppresses type 2 airway inflammation by binding to SPR and regulating its protein expression in a non-enzymatic manner. Phytomedicine. 2023 Mar;111:154657.
(3) Zheng J#, Yao L#, Zhou Y, Gu X, Wang C, Bao K, Sun Y, Hong M. A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis. Cell Death Dis. 2021 Sep 24;12(10):871.
(4) Zheng J#, Wang X#, Tao Y, Wang Y, Yu X, Liu H, Ji L, Bao K, Wang C, Jia Z, Hong M. Yu-Ping-Feng-San ameliorates recurrent allergic inflammation of atopic dermatitis by repairing tight junction defects of the epithelial barrier. Phytomedicine. 2019 Feb 15;54:214-223.
(5) Zheng J, van de Veerdonk FL, Crossland KL, Smeekens SP, Chan CM, Al Shehri T, Abinun M, Gennery AR, Mann J, Lendrem DW, Netea MG, Rowan AD, Lilic D. Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC). Eur J Immunol. 2015 Oct;45(10):2834-46.